Three people have been injured following the crash on SH2, near Apata Station Road.
"One person is seriously injured and a helicopter has been requested," says a statement from police.
"The road is closed and diversion are in place. The serious crash uinit has been advised."
The NZTA says SH2 is currently closed between Esdaile Road and Wainui South Road.
“The NZ Transport Agency is advising people to please delay their journeys or avoid the area if possible.
“People can stay up to date by calling 0800 4 HIGHWAYS or they can check for state highway closures on the website.”